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SLC7A5, a crucial amino acid transporter, likely contributes to ferroptosis susceptibility by altering intracellular amino acid pools, potentially impacting glutathione synthesis and, consequently, GPX4 activity

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In addition, both preclinical and clinical literature often underrepresent females, limiting insights into sex-specific immunometabolic and hormonal modulators of treatment response (Seyedinia et al., 2023

It is also widely used in dermatology for skin-lightening and anti-aging treatments